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Get 10% Discount Apply Coupon Code "USA10" The main indication for the prescription drug tramadol is the management of moderate to severe pain. Being an opioid analgesic, it reduces pain by binding to opioid receptors in the brain and spinal cord. Apart from its analgesic effects, tramadol possesses certain antidepressant characteristics. Serotonin and norepinephrine are two neurotransmitters implicated in pain perception, and tramadol acts by preventing their reuptake. Its ability to relieve pain is also aided by its modest agonistic activity on the mu-opioid receptor.