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OxyContin, a powerful prescription pain medication, is commonly used to manage moderate to severe pain. However, it is important to be aware of potential drug interactions when taking OxyContin. It is crucial to always inform your healthcare provider of all medications you are currently taking, including over-the-counter drugs, vitamins, and supplements, to avoid any potentially harmful interactions. One of the most dangerous drug interactions with OxyContin is with central nervous system depressants, such as benzodiazepines or alcohol. Combining OxyContin with these substances can lead to severe respiratory depression, coma, or even death. It is important to never mix OxyContin with alcohol or other CNS depressants without consulting your healthcare provider first. Additionally, certain medications can affect the way OxyContin is metabolized in the body, leading to either increased or decreased levels of the drug in the bloodstream. Drugs like rifampin, carbamazepine, and phenytoin can reduce the effectiveness of OxyContin, while inhibitors like fluvoxamine and ciprofloxacin can increase its potency. These interactions can lead to serious side effects or reduced efficacy of OxyContin, so it is crucial to discuss any potential drug interactions with your healthcare provider before starting OxyContin.